THEORY OF PARTIAL AGONIST ACTIVITY OF STEROID HORMONES

Theory of partial agonist activity of steroid hormones

The different amounts of residual partial agonist activity (PAA) of GAGS antisteroids under assorted conditions have long been useful in clinical applications but remain largely unexplained.Not only does a given antagonist often afford unequal induction for multiple genes in the same cell but also the activity of the same antisteroid with the same

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Phase 1 Study of Neoadjuvant Short-Course Radiation Therapy Concurrent With Infusional 5-Fluorouracil for the Treatment of Locally Advanced Rectal Cancer

Purpose: To assess the safety and feasibility of neoadjuvant short-course radiation therapy (RT) concurrent with continuous infusion 5-fluorouracil (5-FU) for the treatment of locally advanced rectal cancer.Methods Lip and Materials: Patients with cT3-4 or N + rectal adenocarcinoma based on ultrasound or magnetic resonance imaging were prospectivel

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